# Course Observation Keywords: disease progression, multiple sclerosis, therapy side effects, neurological examinations, MRI, cognitive abilities, quality of life > This page provides information on monitoring disease progression, therapy side effects, and functional impairments in patients with multiple sclerosis through various diagnostic methods and regular evaluations. ## Details - [Course Observation](#): Regular check-ups, including blood and urine tests, and MRI scans, are conducted to monitor disease activity and therapy side effects. - [Neurological Examinations](#): Frequent assessments during the first year of MS therapy help detect nerve system impairments, such as reflex anomalies and motor function changes. - [Magnetic Resonance Imaging (MRI)](#): MRI scans reveal inflammation and assess disease activity, aiding in therapeutic decision-making and tracking new lesions. - [Monitoring Side Effects](#): Blood tests are used to observe therapy-related side effects, with frequency depending on the specific treatment. - [Cognitive Abilities and Quality of Life](#): Neuropsychological tests and questionnaires evaluate the impact of therapy on mental functions, fatigue, and overall life quality.